Plasma PCSK9 levels increase following percutaneous coronary interventions

Abstract Background Beside its role in cholesterol homeostasis, Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) has been associated with the processes of vascular inflammation and atherosclerosis. The protein is expressed endothelial cells, smooth muscle cells macrophages it detected inside human atherosclerotic plaque. Purpose We aimed to investigate effect acute plaque rupture injury during elective percutaneous coronary intervention (PCI) on plasma levels PCSK9 patients artery disease (CAD). Methods measured PCSK9, C-reactive (CRP), Interleukin-6 (IL-6) high-sensitivity cardiac Troponin T (hs-cTnT) immediately before 18–24 hours after PCI via radial approach, 68 consecutive stable CAD referred for a de novo lesion native artery. Patients unstable syndrome <3 months old, baseline inflammatory condition, malignancy, auto-immune or femoral access, were excluded. Results All treated balloon angioplasty implantation second-generation drug eluting stent (DES). Baseline higher women statins. At procedure, CRP, IL-6 hs-cTnT increased significantly compared (table). change (elevation) CRP was statistically correlated that (r=0.33; p=0.006) (r=0.28; p=0.023). However, there no correlation between those (r=−0.09; p=0.47), (r=0.01; p=0.9), (r=0.1; p=0.41). Conclusions Plasma by 26% following DES. That elevation however, not degree myocardial (IL-6 CRP). mechanism underlying PCK9 post requires further investigation. Funding Acknowledgement Type funding sources: None.